Berlin – Communicable Diseases Research

SARS-CoV-2 infection dynamics revealed by wastewater sequencing analysis and deconvolution

Article

Published on 2022-12-202022-11-15
Journal: The Science of the total environment
[Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제,

Mobility in pandemic times: Exploring changes and long-term effects of COVID-19 on urban mobility behavior

Research article

Published on 2022-09-012022-10-05
Journal: Transportation Research Interdisciplinary Perspectives
[Category] 변종,

[키워드] Analysis average Berlin change contribute COVID-19 COVID-19 pandemic decrease Effect Effects Frequency indicated individual lack lockdown longitudinal analysis Mobility Mode choice pandemic Perspective Public Quantitative analysis recorded reduced reduction response suffered Travel Travel behavior Travel patterns unique virus
[DOI] 10.1016/j.trip.2022.100668 [Article Type] Research article

Assessing and improving the validity of COVID-19 autopsy studies – A multicentre approach to establish essential standards for immunohistochemical and ultrastructural analyses

Research article

Published on 2022-08-022022-10-05
Journal: EBioMedicine
[Category] Coronavirus, SARS, 치료기술,

[키워드] Alliance Analysis analysis antibody approach Assessing Autopsy autopsy study available data Berlin cell line cellular structure center correlated COVID-19 criteria education Effect Effects electron microscopy evaluated finding foundation funding Guidance help high variability highest IHC immune response immunohistochemistry Interpretation Microscopy Ministry of Health multicentre organ organ damage pathology pathophysiology positive correlation Protein provided Quantitative recommendation reproducibility RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 nucleocapsid SARS-CoV-2 viral RNA Sensitivity and specificity specificity the SARS-CoV-2 tissue tissues university Validity Variability Viral protein virus
[DOI] 10.1016/j.ebiom.2022.104193 [Article Type] Research article

Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19 (OVID): a randomised, open-label, parallel-group, multicentre, phase 3 trial

Clinical Trial

Published on 2022-08-012022-10-05
Journal: The Lancet. Haematology
[Category] COVID19(2023년), SARS, 임상, 치료제,

[키워드] 1:1 95% CI acute COVID-19 adjusted relative risk age Anti-inflammatory effects Antithrombotic antiviral properties assigned assumption Berlin body temperature clinically Control control group COVID-19 criteria death Efficacy eight eligible enoxaparin event rates foundation futility Germany heparin hospitalisation independent initial intention-to-treat population interim analysis investigator-initiated IQR Johanna major bleeding major bleeding event median age multicentre nine not reduce Older older patient Open-label outcome Outpatient parallel-group participant phase 3 trial Prevent Primary outcome Probability prothrombotic randomisation randomised Randomly receive Registered reported respiratory infection respiratory symptom risk Safety Monitoring Board Serious Adverse Event Standard of care statistical Study design study population Switzerland symptomatic Thromboprophylaxis Treatment Trial university University of Zurich was done were recorded with COVID-19 women
[DOI] 10.1016/S2352-3026(22)00175-2 PMC 바로가기 [Article Type] Clinical Trial

A multiplex protein panel assay for severity prediction and outcome prognosis in patients with COVID-19: An observational multi-cohort study

Research article

Published on 2022-06-092022-10-05
Journal: EClinicalMedicine
[Category] 바이오마커, 임상,

[키워드] accelerate Accuracy agency APACHE II assessment Berlin Biomarker Biomarkers Charité clinical clinical disease progression Clinical outcome clinical risk clinical trials Cohort conducted Council COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 severity death Dexamethasone disease prognosis disease severity education ERC European finding foundation funding Germany hallmark Healthcare system healthy individuals help hospitalised introduced LC-MS/MS LLOQ machine learning median Medicine Mild Mobility moderate multiplex node observational study outcome Patient patient cohort patients with COVID-19 peptide peptides predicted Prognosis Prognostic value Protein proteomics quantification Registered registry Research resource SARS-CoV2 Science sensitivity severe COVID-19 severity Severity stratification SOFA Spectrometry Standard of care stratified Support supported survival System targeted proteomics the median the WHO Therapies Treatment Wellcome Trust
[DOI] 10.1016/j.eclinm.2022.101495 [Article Type] Research article

CytoSorb Rescue for COVID-19 Patients With Vasoplegic Shock and Multiple Organ Failure: A Prospective, Open-Label, Randomized Controlled Pilot Study

Randomized Controlled Trial

Published on 2022-06-012022-10-04
Journal: Critical Care Medicine
[Category] 임상,

[키워드] 1:1 95% CI adjusted Adsorption adverse event age Antibiotics Berlin C-reactive protein clinical concentrations control group Controlled COVID-19 COVID-19 patient COVID-19 patients cytokine dose Effect Endpoint enrolled excluded Gender greater groups hazard ratio Hemodialysis ICU IMPROVE inflammatory markers interleukin-6 interquartile range IQR junction measurement median membrane Monmouth Mortality mortality rate Multiple one patient Patient pilot study primary endpoint Prospective Randomized receive reduction Registered registry rescue Resolution secondary Secondary endpoints Shock Standard of care Standard therapy study inclusion the primary endpoint treatment group university hospital variable Withdrawal
[DOI] 10.1097/CCM.0000000000005493 PMC 바로가기 [Article Type] Randomized Controlled Trial

Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19

Research article

Published on 2022-05-142022-10-05
Journal: EClinicalMedicine
[Category] 진단, 치료기술,

[키워드] adaptive Adaptive immune response analyzed Antigen association Berlin cell counts cell types characterized clinical Clinical course Clinical management clone controls coronavirus coronavirus disease COVID-19 COVID-19 disease severity Critical cross-sectional decrease Disease progression disease severity distribution enrichment examined figure finding funding group healthy healthy control healthy subject heavy chain highest highlighting HLA immune Immune receptor Immune repertoires immune response Immunoglobulin IMPROVE increase in leukocyte lymphocyte measure Metadata Mild outbreak Peripheral blood Predictive Probability progression receptor SARS-CoV-2 scale sequence Sequencing severe COVID-19 severe COVID-19 disease severity subject subjects T cell T cell receptor T cells target the disease Therapies TRB TRD understanding variable with COVID-19 World Health Organization
[DOI] 10.1016/j.eclinm.2022.101438 [Article Type] Research article

Timely Monitoring COVID-19 Vaccine Protection, Berlin, Germany, April 15th to December 15th, 2021

시기 적절한 모니터링 COVID-19 백신 보호, 독일 베를린, 2021년 4월 15일~12월 15일

Article

Published on 2022-03-212022-09-11
Journal: International Journal of Public Health
[Category] SARS, 변종,

[키워드] Abstract Berlin booster booster vaccination COVID-19 Germany monitoring protection SARS-CoV-2 SARS-CoV-2 variants Surveillance Vaccine vaccine effectiveness vaccine protection Vaccines waning immunity Waning Immunity.
[DOI] 10.3389/ijph.2022.1604633 PMC 바로가기 [Article Type] Article

Limitations of the ARDS criteria during high-flow oxygen or non-invasive ventilation: evidence from critically ill COVID-19 patients

Observational Study

Published on 2022-03-072022-10-04
Journal: Critical Care
[Category] MERS, SARS, 임상,

[키워드] acute respiratory distress acute respiratory distress syndrome Analysis ARDS Berlin caused change COVID-19 patient criteria Critically ill Critically ill patient Evidence HFNC High-flow oxygen Hypothesis Hypoxemia ICU increase in increasingly indicate inspired oxygen fraction intensive care Invasive mechanical ventilation investigated limitation mechanical ventilation median Mild moderate nasal NIV Non-invasive Non-invasive respiratory support non-invasive ventilation oxygen pandemic PaO Patient prospective observational study provided pulmonary damage Respiratory failure Respiratory function Respiratory Support Result SARS-CoV2 severity single-center Steady state switching syndrome Uppsala University Variation ventilated patient was recorded with COVID-19
[DOI] 10.1186/s13054-022-03933-1 PMC 바로가기 [Article Type] Observational Study

Comparison between methylprednisolone infusion and dexamethasone in COVID-19 ARDS mechanically ventilated patients

Research

Published on 2022-02-152022-10-31
Journal: The Egyptian Journal of Internal Medicine
[Category] COVID-19,

[키워드] acute respiratory distress Analysis ARDS Berlin both group caused Chest Clinical outcome coronavirus Coronavirus disease 2019 Corticosteroid Course COVID-19 COVID-19 pneumonia CRP Cytokine storm D-dimer decrease Dexamethasone diagnosed discharge dose effective effective therapy evaluated ferritin fraction Ground glass opacity ICU inclusion criteria Inflammatory marker intensive care intensive care patient invasive mechanical laboratory result LDH less lymphocyte marker material mechanical ventilation mechanically ventilated mechanically ventilated patient Methylprednisolone methylprednisolone group Mortality neutrophil optimal dose overall mortality oxygen oxygen supplementation P/F ratio Patient patients treated Pneumonia polymerase chain Previous studies prospective cohort study Protein radiological radiological finding required Result SARS-CoV-2 SARS-CoV-2 pneumonia Severe COVID-19 pneumonia severity statistically significant Steroids survival syndrome the patient tomography treated Treatment university were given
[DOI] 10.1186/s43162-022-00113-z PMC 바로가기 [Article Type] Research